Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases.Learn:What is cortisol and what does it do?Is  cortisol bad?Should you worry about cortisol increases with exercise?Should you take supplements to lower cortisol?and more

Drs. Karl and Spencer discuss their ideal healthcare delivery system.Learn:Spencer's journey building and selling Sequence and what he wants to do next.How Dr. Karl believes healthcare should be and what he's doing next.Click here to get on Dr. Spencer's waitlist 

Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials.Are there any supplements that can mimic Ozempic?What is amylin and how does it help with weight and sugars?What is this new oral drug "amycretin" in phase 1 trials?and more

Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause.Learn:How it's diagnosed.When and when not to treat.The various treatment.If it is indicated for cardiovascular disease prevention or body composition.Whether or not you should get labs.See more at Dr. Gunter's website 

Drs. Karl and Spencer talk about the top line results from study showing liraglutide may have some benefit in Alzheimer's along with top line results from the Summit trial showing heart failure benefits with tirzepatide.They also discuss the women's boxing controversy and BMI in athletes.

Drs. Karl and Spencer chat with return guest and bone expert endocrinologist Dr. Rachel Pessah-Pollack all about the new Vitamin D guidelines.Should healthy people even check a vitamin D level?Should they supplement with vitamin D?What people should check or supplement?Click here for the new guidelines 

Does semaglutide cause blindness?What is NAION (nonarteritic anterio ischemic optic neuropathy)?What about worsening of diabetic retinopathy with semaglutide?What can you do to minimize the risk of NAION and retinopathy?Get the full study hereRead Dr. Brugger's blog

Tirzepatide may be a good option if you have obesity and obstructive sleep apnea.Click here to read the study

Click here to read about the gastric ablation and trial.Click here to see Dr. McGowan's clinic

Drs. Karl and Spencer discuss the recent FLOW trial where semaglutide was found to be kidney protective. They also go off about the costs of these medicines and what to do (including compounding considerations). Click here to see the study

Drs. Karl and Spencer discuss the most recent South Park episode where GLP-1 medicines are discussed along with the dysfunctions of our healthcare system among other issues.

Drs. Karl and Spencer discuss the fallacies of functional medicine. You'll learn what functional medicine is and whether you should seek it out.

Drs. Karl and Spencer respond to Jillian Michaels on the Bill Maher show

Drs. Karl and Spencer discuss with gastroenterologist Dr. McGowan all about endoscopic gastroplasty. See recent study on cost effectiveness of endoscopic gastroplasty vs semaglutide Check out his program

Drs. Karl and Spencer discuss the new studies about GLP-1 medicines and Parkinson's and heart failure along with how these meds are not just weight loss drugs but health promoting medicines. Click here to see the Parkinson's study Click here to see the heart failure study

Drs. Karl and Spencer chat with Kasey Potts all about her journey with lipedema. Learn more about how this condition is diagnosed and treated. Check out her instagram

Drs. Karl and Spencer chat with Dr. Amron all about lipedema. He is a specialized surgeon who treats lipedema daily. Learn about diagnosing and treating this condition that is commonly mistaken with obesity. Check his sites https://www.dramronconsultations.com/ https://www.advancedlipedematreatment.com/

Drs. Karl and Spencer discuss a new study showcasing the importance of exercise during and after GLP-1 medicine use. Click here to see the original study Click here to see the extension study

Drs. Karl and Spencer discuss a recent Mark Hyman podcast where he perpetuated some myths about obesity and GLP-1 receptor agonist medicines.

Drs. Karl and Spencer discuss whether your doctor needs to look a certain way in order to be a good doctor.

Drs. Karl and Spencer chat with Drs. Jess and Andrea all about popular podcasters like Andrew Huberman etc. and the spread of pseudoscience.

Drs. Karl and Spencer chat about their now defunct supplement company along with the ethics of big pharma direct to consumer marketing (including influencers).

Drs. Karl and Spencer chat with Dr. Brianna Durand all about the pelvic floor and incontinence when lifting etc. empower.physio pelvicrehab.org

Drs. Karl and Spencer chat with Dr. Stuart Phillips all about protein. How much do you need to eat for optimal health and body composition and more!

Drs. Karl and Spencer chat with Dr. Nicola Guess all about the evidence behind using continuous glucose monitors in those without type 2 diabetes. Learn whether they are useful for even harmful Read her review paper here

Drs. Karl and Spencer discuss the new SELECT results that show a decrease in cardiovascular events in those taking Wegovy who have a history of cardiovascular disease. See trial below https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

Drs. Karl and Spencer discuss how tirzepatide is now approved for obesity. Learn: When will it be available How much will is cost Any differences compared to Mounjaro Surmount 3 trial

Drs. Karl and Spencer chat with Dr. Kathleen Keller and Yash Adroja all about brain signaling in kids in relation to obesity. Learn all about Dr. Keller's research that sheds light on taste preferences and food choices made by kids.

Drs. Karl and Spencer chat about some of the new tirzepatide studies including SURMOUNT-4 from the EASD

Drs. Karl and Spencer discuss with Dr. Bassin all about her review on exercise and physical activity for type 2 diabetes. Check out her review article

Drs. Karl and Spencer discuss how semaglutide impacts the heart with new trial data available. Learn how semaglutide may reduce risks of heart attacks and also how it impacts your quality of life if you have heart failure.

Drs. Karl and Spencer chat with Dr. Andrea Love all about the microbiome. Find out if it really matters and if there are things to improve it.

Drs. Karl and Spencer chat with Amy Goekel about her history of her eating disorder. Amy has her own podcast where she discusses it is more depth as well https://podcasts.apple.com/us/podcast/the-eating-disorder-diaries/id1666122772

Drs. Karl and Spencer chat with Dr. Andrea Love, a cancer immunologist, about the recent headlines about the WHO listing aspartame as a possible carcinogen.

Drs. Karl and Spencer chat with Dr. Pearl all about internalized bias and her recent study on it Click here to read the study

Drs. Karl and Spencer chat with Dr. Jesse Richards all about BBS (Bardet Biedl Syndrome), an unknown cause of genetic obesity.

Drs. Karl and Spencer sit with Dr. Nagra to discuss the recent WHO news headlines about artificial sweeteners. Find out why you should still drink diet soda instead of regular soda.

Drs. Karl and Spencer chat with Dr. Salas-Whalen, an endocrinologist, about getting the appropriate clinician to prescribe you GLP-1 medicines.

Drs. Karl and Spencer discuss with cardiologist Dr. Luke Laffin about his recent study looking at statins versus various supplements touted as cholesterol-lowering. We also discuss the claim about saunas being better than drugs at lowering mortality.

Drs. Karl and Spencer chat with Dr. Angela Fitch, the president of the Obesity Medicine Association and a fellow doc who lifts! They discuss Dr. Fitch's journey into lifting along with the importance of body composition in obesity management. Dr. Fitch is also the CMO of her new company KnownWell. Need an online workout program? Check out LiftRx

Drs. Karl and Spencer bring back Dr. Grant Tinsley, a body composition researcher, to go over the GLP-1 data (semaglutide and tirzepatide) in terms of lean body mass loss. Learn: - How much lean body mass is lost in these trials - How body composition is measured - How is muscle loss assessed - Should you be worried if you're taking a GLP-1 agonist Read Dr. Tinsley's blog Become a Sequence patient (evaluation for GLP-1 agonist)

Drs. Karl and Spencer discuss whether we should call lifestyle measures "medicine".

Drs. Karl and Spencer discuss the drugs that help you pee out calories - SGLT2 inhibitors. Learn how this type 2 diabetes medicine has turned into a great drug for other conditions.

Drs. Karl and Spencer go over the common myths of the GLP-1 agonists. Is Ozempic face real? Do people get pancreatic cancer or pancreatitis? Find out by listening!

Drs. Karl and Spencer chat with Dr. Leslie Golden about the troubles with insurance covering obesity medicine.

Drs. Karl and Spencer sit down with Dr. Nicola Guess, an RD PhD scientist, to discuss the new alarming study regarding erythritol. Read the review that goes over the endogenous vs exogenous erythritol

Drs. Karl and Spencer discuss the worry surrounding lean mass loss while using GLP-1 agonists. Learn: - The usual amount of lean mass loss during weight loss - How much was lost in small subset using semaglutide and tirzepatide - What is the clinical relevance - and more!

Drs. Karl and Spencer discuss the phenomena of those who believe cholesterol (and lipoproteins that carry cholesterol) doesn't cause heart disease. Learn: - How Dr. Spencer was also a skeptic when first starting medical school - How the data are pretty overwhelming for cholesterol/apoB/LDL particles causing heart disease

Drs. Karl and Spencer talk with fellow Docs Who Lift and the team of Barbell Medicine Drs. Jordan Feigenbaum and Austin Baraki about the harms of the various hormone clinics out there along with ordering large batteries of tests. Hear Dr. Austin's case study where a huge number of tests were ordered only to give the patient thousands of dollars of supplements and drugs they didn't even need. And get this... they didn't even address the one issue they were having.

Drs. Karl and Spencer chat with Dr. Zeena Al-Rufaie, a pediatric obesity specialist, about the new pediatric obesity guidelines. She gives her own experience as a mother and also a pediatrician about the new guidelines that caused media headlines to spin out of control.

Drs. Karl and Spencer discuss the recent 60 minutes interview where genetics were said to be the number 1 cause of obesity. Learn: - about the outrage that ensued - how the environment and genetics cause obesity together - why some don't get obesity despite the environment - why some need tools to fight back If needing medical tools to fight back, work with Dr. Spencer's group online.

Drs. Karl and Spencer chat with Abby Langer and Amanda Thebe all about the various red flags you see with quacks online. What are the top nutrition red flags? What about those preying on women going through menopause? and more!

Drs. Karl and Spencer discuss the new pediatric obesity guidelines that have caused an uproar in the media. Are they really pushing drugs and surgery before lifestyle? Find out! Click here to read the actual guidelines

Drs. Karl and Spencer discuss a tweet from Steve Crowder. Learn more about judging health by looks (and obesity)

Drs. Karl and Spencer discuss with Dr. Guillermo Escalante all about the harmful effects of anabolic steroids. Dr. Escalante published a study on autopsies done on bodybuilders who died young. Learn: How anabolic steroids affect the heart Whether there are intrinsic factors beyond blood pressure and lipids Dr. Spencer's patients who use steroids and how he tries to keep them as healthy as possible

Drs. Karl and Spencer discuss diet zealots and evangelicals. Learn: What to look out for this New Year so you don't get duped into another diet cult

Drs. Karl and Spencer discuss how home body fat scales work and Dr. Tinsley's newest study on their accuracy. Learn: How various methods measure body composition The various compartments How bioimpedance scales work and what the most accurate at home scales are available See Dr. Tinsley's article all about it here

Drs. Karl and Spencer continue the conversation with The Farm Babe all about ethical farming etc. Find The Farm Babe on: Instagram and Facebook

Drs. Karl and Spencer discuss agriculture and farming with The Farm Babe. This is part 1 of a 2 part series Learn about safe farming practices and ethical concerns of raising and eating animals and much more. Follow the farm babe by clicking here

Drs. Karl and Spencer discuss the false dichotomy of believing one needs to only do lifestyle OR take a medicine.

Drs. Karl and Spencer chat with the Food Science Babe all about food science and fear mongering. Get some insight into: GMOs Food additives and shelf-life of foods Learn more by checking out Food Science Babe's instagram

Drs. Karl and Spencer discuss a few things from Obesity Week (the big obesity conference in the United States). Learn about: - Dr. Spencer's debate on resistance versus aerobic training. - Some obesity genetics. - and new therapies being studied for obesity. https://liftrx.com/

Drs. Karl and Spencer chat with trainer Dontae Burks about his experience with training young children all the way up to the elderly. What's the best way to get kids to work out? Should kids even lift weights? and more!

Drs. Karl and Spencer go over the medicines that treat prediabetes and type 2 diabetes. Learn: - Whether you should even treat prediabetes - If you should do medicine before lifestyle - All about metformin - and of course GLP-1s

Drs. Karl and Spencer discuss the new trend of Hollywood stars using GLP-1 agonists for vanity weight loss and the new weight loss guidelines for medicine and surgery. JoinSequence.com

Drs. Karl and Spencer discuss diabetes. What are the different types? What causes these different types? How can you prevent and treat with lifestyle?

Drs. Karl and Spencer discuss with Examine.com director Kamal Patel all about supplements. Which ones should you take? Which ones should you avoid? Are fat burners worthwhile? What about testosterone boosters? Find out in this episode.

Drs. Karl and Spencer discuss a couple metabolic case studies where weight loss is indicated and helpful. For nutrition coaching go to: https://bigrocksnutrition.com/

Drs. Karl and Spencer discuss with Dr. Kevin Klatt, an RD PhD, on whether or not to even pay attention to media headlines about nutrition science. 

Drs. Karl and Spencer sit down with neurobiologist and obesity researcher Dr. Stephan Guyenet to discuss how the brain is the main organ involved in obesity. Learn: How the brain regulates our body fatness The difference between hunger and cravings Why we eat How the new GLP-1 class of medicines help Visit his blog  See if you qualify for the GLP-1 medicines

Drs. Karl and Spencer discuss with endocrinologist Dr. Bonnecaze all about male obesity-related secondary hypogonadism (low testosterone). Learn: - How obesity causes low testosterone - What to do about it For workouts click here For nutrition help click here For medical weight loss click here 

Drs. Karl and Spencer discuss with Dr. Pessah-Pollack, an osteoporosis focused endocrinologist, all about osteoporosis. Learn: The risk factors for osteoporosis How to screen for it How prevent it Why you should care Use LiftRx to prevent osteoporosis

Drs. Karl and Spencer sit down with bariatric surgeon Dr. Garth Davis to discuss the ins and outs of surgery for weight loss. Learn: The types of surgery Whether it is safe or not How well does it work And whether Garth lifts or not.

Drs. Spencer and Karl sit down with Ted Kyle to discuss his recent mentions on the Bill Maher show. We go over Ted's advocacy in obesity and how Bill misrepresented Ted's out-of-context quotes.  Visit Ted's website here

Drs. Karl and Spencer discuss with Hormones Demystified, an endocrinologist, about testing for hypothyroidism. Learn: - The basics of testing - Whether TSH is enough - If you need antibodies - If reverse T3 and free T3 are needed - and more! Get Dr. Spencer's Free Start Here guide - download here See Hormones Demystified blog to learn much more about the thyroid

Drs. Karl and Spencer discuss the origin story of Hormones Demystified and how people get sucked into pseudoscience quackery. Hormones Demystified is one of the top myth busting blogs out there dedicated to discussing hormones. The person behind the blog is anonymous, but you get an inside scoop right here. This is part 1 of a 2 part series.  Click here to check out HormonesDemystified.com

Drs. Karl and Spencer discuss the newly FDA approved medicine Mounjaro (Tirzepatide) and its effect on sugars and weight. It works similarly to the other GLP-1 meds... but better. Learn: How it works How well it works and if you should look into it. go to joinsequence.com if interested 

Drs. Karl and Spencer have fellow Doc Who Lifts Dr. Bonnecaze back on the show to discuss hypogonadism (low testosterone) in men. Learn: The signs and symptoms of hypogonadism Whether you should get tested or not How to test properly And why most people do it wrong Go to LiftRx to get Dr. Spencer's monthly workout program.

Drs. Karl and Spencer discuss the most powerful medicines currently available for weight loss - the GLP-1s. Learn: How these medicines work How much weight loss on average to expect from these medicine The possible side effects and how to minimize them Go to JoinSequence.com to see if you're eligible for one

Drs. Karl and Spencer discuss the weight loss effects of phentermine, Qsymia (phentermine/topiramate), and Contrave (bupropion/naltrexone). Learn: How each of these medicines work. How effective each medicine is. Who shouldn't take these medicines. Go to JoinSequence.com for Dr. Spencer's telemedicine program

Drs. Karl and Spencer go over the indications for taking medicines for weight loss. Dr. Spencer's online clinic -> JoinSequence.com

Drs. Karl and Spencer discuss whether your hormones are stopping you from weight loss. Learn: Secondary hormonal causes of obesity Is it your thyroid? Cushing's (or other high cortisol causes) Is it all calories in versus out? and more

Drs. Karl and Spencer aren't actual vegans, but they did a vegan stint for a month. Take a listen to hear what happened. Learn: What happened to their strength, lipids, and body composition. How Dr. Spencer almost puked from vegan "junk food". Whether or not you can be healthy eating meat.

Drs. Karl and Spencer Nadolsky discuss the new study on intermittent fasting from the New England Journal of Medicine. You'll learn: - What types of intermittent fasting methods are out there - If they help you lose weight more than just cutting calories in general - If there are other benefits beyond the calorie restriction The NEJM Study Other new study mentioned from the journal Obesity

Drs. Karl and Spencer discuss the idea behind metabolically healthy obesity (MHO). Learn: - If it is possible to have obesity and be "healthy" - What entails "health" - How to get healthier Recent review LiftRx.com 

The medical diagnosis of obesity isn't as simple as a BMI anymore. Take a listen to Drs. Karl and Spencer Nadolsky discuss how it should be diagnosed when you walk into a doctor's office. AACE Obesity Guidelines

Drs. Karl and Spencer Nadolsky discuss why you're tired and how it is not adrenal fatigue. Learn: - Adrenal gland physiology and pathology - What "adrenal fatigue" allegedly is - Other causes of fatigue - What to do about it

Drs. Spencer and Karl discuss carbs, insulin, and their role in weight loss and obesity. Recent review on energy balance -> Click Here DIETFITS Study -> Click Here