Manu Prakash is a professor of bioengineering at Stanford University, asking biological questions with insights from physics. His most widely known contribution is the FoldScope, a $1-microscope made from paper and a lens – 2 million copies of this have been distributed to would-be scientists around the world. In this episode, Manu emphasizes how science is a sense of wonder and a personal journey with no set roads. To get to new and deep questions, Manu feels he needs to “embed” himself in the world he's studying, e.g., by spending weeks on research vessels on the open sea when he’s interested in deep-sea biology. In his view, the most important consequence of a discovery is not how it impacts the world, but how it changes the scientist making the discovery.This episode was supported by Research Theory (researchtheory.org). For more information about Night Science, visit https://www.biomedcentral.com/collections/night-science .

Tom Mullaney is a Professor of History at Stanford University and the Kluge Chair in Technology and Society at the Library of Congress, and Chris Rea is a Professor of Asian Studies at the University of British Columbia. In 2022, Tom and Chris published the book ‘Where Research Begins: Choosing a Research Project That Matters to You (and the World)’. In this episode, we talk about self-centered research (and about getting over yourself), how vulnerable self-confidence empowers your research, and how your personal biases are necessary for you to notice anything interesting at all. For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science  .

Yukiko Yamashita is a biology professor at MIT and an investigator at the Howard Hughes Medical Institute. Yukiko’s research is amazingly broad, perhaps because she often only realizes at the end of a project which question she was asking by what she had been doing, as she explains in this episode. She likens research to solving 5000-piece jigsaw puzzles – not one at a time, but with the pieces from hundreds of puzzles all dumped together. So that while we put the pieces together, we have to be always watching ourselves: does that come from the same picture? Yukiko sees her role in the lab like that of an old wise woman in a tribe, a kind of ancient memory that still remembers their conversation with former lab members – stimulating creativity by bridging projects and generations of researchers.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science  .